Highly Enantioselective Chlorination of β-Keto Esters and Subsequent SN2 Displacement of Tertiary Chlorides: A Flexible Method for the Construction of Quaternary Stereogenic Centers

Kazutaka Shibatomi, Yoshinori Soga, Akira Narayama, Ikuhide Fujisawa, and Seiji Iwasa

 J. Am. Chem. Soc., 2012, 134 (24), pp 9836–9839 

DOI: 10.1021/ja304806j