Design and synthesis of 4-alkynyl pyrazoles as inhibitors of PDE4: A practical access via Pd/C–Cu catalysis

Dhilli Rao Gorja, K. Shiva Kumar, Ajit Kandale, Chandana Lakshmi T. Meda, Kishore V.L. Parsa, K. Mukkanti, Manojit Pal

Bioorganic & Medicinal Chemistry Letters
Volume 22, Issue 7, 1 April 2012, Pages 2480–2487

http://dx.doi.org/10.1016/j.bmcl.2012.02.008